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Kesavan V

kesavan-v
Associate Professor
Ph.D, Indian Institute of Science
M.Sc, Madurai Kamaraj University
Office: BT 405
Tel: +91-44-2257-4124
Email: vkesavan@iitm·ac·in
Lab: BT 417 (Website)

Research Interests

  • Design and synthesis of novel privileged chiral ligands for asymmetric catalysis
  • Design novel non-hydroxamate inhibitors against HDAC to treat cancer
  • Peptide mini-vectors for delivery of siRNAs

Publications

  • Soutschek, J.; Akinc, A.; Bramlage B.; Charisse K.; Constien, R. ; Donoghue, M.; Elbashir, S.; Geick, A.; Hadwiger, P.; Harborth, J.; John, M.; Kesavan, V.; Lavine, G.; Pandey, R.; Racie, T.; Kallanthottathil, R.; Rohl, I.; Toudjarska, I.; Wang, G.; Wuschko, S.; Bumcrot, D.; Koteliansky, V.; Limmer, S.; Manoharan, M.; Vornlocher, H-P. Therapeutic Silencing In Vivo of an Endogenous Gene by Systemic Administration of Modified siRNAs. Nature, 2004, 432, (7014), 173-178.
  • Ravikumar, K. S.; Kesavan, V.; Crousse, B.; Bonnet-Delpon, D.; Begue, J-P.. Mild and selective oxidation of sulfur compounds in trifluoroethanol: Diphenyl disulfide and methyl phenyl sulfoxide. Organic Syntheses 2003, 80 184-189.
  • Kesavan, V.; Tamilarasu, N; Cao, H; Rana, T. M. A new class of RNA-binding oligomers: Peptoid amide and ester analogues. Bioconjugate Chemistry 2002, 13(6), 1171-1175.
  • Kesavan, V.; Dhar, D; Koltypin, Y.; Perkas, N.; Palchik, O.; Gedanken, A.; Chandrasekaran, S. Studies of catalytic aerobic oxidation with nanostructured amorphous metals, alloys and metal oxides. Journal of Indian Institute of Science, 2002, 82(2), 113-120.
  • Kesavan, V.; Dhar, D.; Koltypin, Y.; Perkas, N.; Palchik, O.; Gedanken, A.; Chandrasekaran, S. Nanostructured amorphous metals, alloys, and metal oxides as new catalysts for oxidation. Pure and Applied Chemistry 2001, 73(1), 85-91.
  • Das, U.; Crousse, B.; Kesavan, V.; Bonnet-Delpon, D.; Begue, J-P. Facile Ring Opening of Oxiranes with Aromatic Amines in Fluoro Alcohols. Journal of Organic Chemistry 2000, 65(20), 6749-6751.
  • Kesavan, V.; Bonnet-Delpon, D.; Begue, J-P.; Srikanth, A.; Chandrasekaran, S. New catalytic oxidation of trifluoromethyl carbinols by a ruthenium(II) complex. Tetrahedron Letters 2000, 41(18), 3327-3330.
  • Kesavan, V. ; Bonnet-Delpon, D.; Begue, J-P. Fluoro alcohol as reaction medium: one-pot synthesis of β-hydroxy sulfoxides from epoxides. Tetrahedron Letters 2000, 41(16), 2895-2898.
  • Kesavan, V.; Bonnet-Delpon, D.; Begue, J-P. Oxidation in fluoro alcohols: mild and efficient preparation of disulfides from thiols. Synthesis 2000, (2), 223-225.
  • Kesavan, V.; Sivanand, P.S.; Chandrasekaran, S.; Koltypin, Y.; Gedanken, A. Catalytic aerobic oxidation of cycloalkanes with nanostructured amorphous metals and alloys. Angewandte Chemie, International Edition 1999, 38(23), 3521-3523.
  • Kesavan, V.; Chandrasekaran, S. A Highly β-Stereoselective Catalytic Epoxidation of ?5-Unsaturated Steroids with a Novel Ruthenium(II) Complex under Aerobic Conditions. Journal of Organic Chemistry 1998, 63(20), 6999-7001.
  • Kesavan, V.; Chandrasekaran, S. Stereospecific and regioselective catalytic epoxidation of alkenes by a novel ruthenium(II) complex under aerobic conditions. Journal of the Chemical Society, Perkin Transactions 1. 1997, (21), 3115-3116.

Patents

  • Manoharan, Muthiah; Kesavan, Venkitasamy; Rajeev, Kallanthottathil G. Preparation of cholesterol-chemically modified DNA duolexes and their use for inhibiting gene expression. PCT Int. Appl. (2006), 265 pp. CODEN: PIXXD2 WO 2006020768 A2 20060223 AN 2006:164429
  • Dhanoa, Dale S.; Becker, Oren; Noiman, Silvia; Alla, Sekar Reddy; Cheruku, Srinivasa Rao; Mele’ndez, Rosa E.; Sharadendu, Anurag; Chen, Dongli; Marantz, Yael; Shacham, Sharon; Heifetz, Alexander; Inbal, Boaz; Kesavan, Venkitasamy; Bar-haim, Shay. Preparation of piperidinylamino-thieno[2,3-d]pyrimidine compounds as 5-HT2B modulators. U.S. Pat. Appl. Publ. (2005), 73 pp., Cont.-in-part of U.S. Ser. No. 947,995. CODEN: USXXCO US 2005222176 A1 20051006 CAN 143:367320 AN 2005:1078251
  • Dhanoa, Dale S.; Becker, Oren; Noiman, Silvia; Reddy, Sekar A.; Cheruku, Srinivasa Rao; Mele’ndez, Rosa E.; Sharadendu, Anurag; Chen, Dongli; Marantz, Yael; Shacham, Sharon; Heifetz, Alexander; Inbal, Boaz; Kesavan, Venkitasamy; Bar-haim, Shay. Preparation of piperidinylamino-thieno[2,3-d]pyrimidine compounds as 5-HT2B modulators. U.S. Pat. Appl. Publ. (2005), 73 pp., Cont.-in-part of U.S. Ser. No. 815,417. CODEN: USXXCO US 2005222175 A1 20051006 CAN 143:367319 AN 2005:1078250
  • Manoharan, Muthiah; Kesavan, Venkitasamy; Rajeev, Kallanthottathil G. SiRNA’s containing ribose substitutes to which lipophilic moieties may be attached. U.S. Pat. Appl. Publ. (2005), 273 pp., Cont.-in-part of Appl. No. PCT/US04/011829. CODEN: USXXCO US 2005107325 A1 20050519 CAN 142:477067 AN 2005:431390
  • Dhanoa, D. S.; Becker, O.; Noiman, S.; Cheruku, S.R.; Marantz, Y.; Shachem, S.; Heifetz, A.; Inbal, B.; Kesavan, V.; Bar-haim, S.; Reddy, S.A.; Melendez, R. E.; Sharadendu, A.; Chen, D. New piperidinylamino-thieno[2,3-d]pyrimidine compounds. PCT Int. Appl. (2004), 106 pp. WO 2004089312
  • Becker, O.; Dhanoa, D. S.; Noiman, S.; Sharadendu, A.; Kesavan, V.; Mohanty, P.; Marantz, Y.; Kalid, O.; Chen, D.; Sharon, S.; Nudelman, R. Triazole neurokinin antagonists. PCT Int. Appl. (2004), 67 pp. WO 2004030629.
  • Becker, O.; Chen, D.; Cheruku, S. R.; Dhanoa, D. S.; Heifetz, A.; Kalid, O.; Kesavan, V.; Marantz, Y.; Mohanty, P.; Noiman, S.; Nudelman, R.; Shachem, S.; Sharadendu, A. Preparation of substituted aminopyrimidines as neurokinin antagonists effective for treating CNS disorders. PCT Int. Appl. (2004), 70 pp. WO 2004014850

Honours and Awards

  • Recipient of The Guha Research Medal (best thesis of the Department of Organic Chemistry, IISc, Bangalore, India, for the year 1999-2000).