Elucidating the biosynthetic pathways of volatile organic compounds in Mycobacterium tuberculosis through a computational approach
Microbial volatile organic compounds (VOCs) have gained prominence in the recent past...
How are the Volatile Organic Compounds (VOCs) in tuberculosis synthesised by Mycobacterium tuberculosis?
Are mutational effects localised? If not, is there a general rule for the extent of percolation and the functional form of this propagation?
How do we use computational approaches to re-engineer metabolic networks?
Fast-SL identifies synthetic lethals by an iterative reduction of search space.
Assuming an equal likelihood for all mutations (as in an unweighted network), underestimates robustness and overestimates evolvability of a system.
How effective are systems and control theoretic concepts and techniques in systems and synthetic biology?
How are protein networks organised, structurally, in terms of the connectivity of essential and non-essential proteins?
Does the centrality–lethality hypothesis hold good for different types of organisms?
Do essential proteins hold a special position in the network organisation?
What are the important network metrics that can decide if a protein is likely to be essential?
How can we model complex biological systems at various levels? How can we represent/visualise/analyse massive biological networks? How do biological systems respond to perturbations?
Dates: Feb 6-11, 2017 Venue: Department of Biotechnology, Bhupat and Jyoti Mehta...
Mutations in the hydrophobic interior of proteins are generally thought to weaken...
Robustness and evolvability are highly intertwined properties of biological systems. The relationship...