A General Mechanism for the Propagation of Mutational Effects in Proteins
Mutations in the hydrophobic interior of proteins are generally thought to weaken...
Computational Systems Biology Lab
Karthik Raman's Lab @ IIT Madras
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In Silico Approaches to Metabolic Engineering
With an increasing understanding of the cell at the molecular level, primarily...
Critical assessment of genome-scale metabolic networks: the need for a unified standard
Genome-scale metabolic networks have been reconstructed for several organisms. These metabolic networks...
Revisiting Robustness and Evolvability: Evolution in Weighted Genotype Spaces
Robustness and evolvability are highly intertwined properties of biological systems. The relationship...
A Systems Theoretic Approach to Systems and Synthetic Biology
The complexity of biological systems has intrigued scientists from many disciplines and...
Fast-SL: An efficient algorithm to identify synthetic lethals
Synthetic lethal sets are sets of reactions/genes where only the simultaneous removal...
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