BT 3190 – Metabolic Regulation

On 10 April, 2012


Course contents

  • Overview of cellular metabolism
  • Structure and organisation of metabolic networks
  • Modelling of metabolic networks
  • Enzyme activity: the molecular basis for its regulation; regulation of enzyme activity, regulation of enzyme concentration
  • Regulation at the whole-cell level, regulation of metabolic networks, regulation of central pathways
  • Gene regulatory networks: operons, regulons, stimulons
  • Signal transduction pathways, protein phosphorylation: role of phosphorylation/de-phosphorylation in regulation of enzyme activity
  • Enzymatic, molecular-genetic and hormonal regulation of carbohydrate and lipid metabolism
  • Modelling of metabolic network regulation
  • Metabolic Control Analysis
  • Control structures in metabolism
  • Examples of pathway manipulations, synthesis of metabolic pathways
  • Metabolic regulation in health and disease

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