BT 3190 – Metabolic Regulation
Course contents
- Overview of cellular metabolism
- Structure and organisation of metabolic networks
- Modelling of metabolic networks
- Enzyme activity: the molecular basis for its regulation; regulation of enzyme activity, regulation of enzyme concentration
- Regulation at the whole-cell level, regulation of metabolic networks, regulation of central pathways
- Gene regulatory networks: operons, regulons, stimulons
- Signal transduction pathways, protein phosphorylation: role of phosphorylation/de-phosphorylation in regulation of enzyme activity
- Enzymatic, molecular-genetic and hormonal regulation of carbohydrate and lipid metabolism
- Modelling of metabolic network regulation
- Metabolic Control Analysis
- Control structures in metabolism
- Examples of pathway manipulations, synthesis of metabolic pathways
- Metabolic regulation in health and disease