மனித மரபுத்தொகுதியைப் புரிந்துக்கொள்ள டிஎன்ஏ ஓர் ஆரம்பம் மட்டுமே!
Links
- Embryo Images
- This site has scanning electron micrographs of developing mammalian embryos, mostly mice though there are human embryo pictures. Normal and abnormal development are featured in tutorials based on body parts.
- Of Mice and Men
- From the Howard Hughes Medical Institute, an article on the how gene targetting works in mice.
- Holliday Structure
- A brief description with an animated gif of how strand exchange works between two pieces of DNA.
Bibliography
- Capecchi, M.R., 1997, Hox Genes and Mammalian Development, Cold Spring Harbor Symposia on Quantitative Biology, 62: 273-281.
- Capecchi, M.R., 1989, Altering the Genome by Homologous Recombination, Science, 244: 1288-1292.
- Capecchi, M.R., 1994, Targeted Gene Replacement, Scientific American, March, 52-59.
- Davis, A.P., Witte, D.P., Hsieh-Li, H.M., Potter, S.S., and Capecchi, M.R., 1995, Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11, Nature, 375: 791-795.
- Fukushige, S., Sauer, B., 1992, Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells, Proc. Natl. Acad. Sci., 89: 7905-7909.
- Mansour, S.L., Thomas, K.R., Capecchi, M.R., 1988, Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes, Nature, 336: 348-352.
- Sauer, B., Henderson, N., 1988, Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1, Proc. Natl. Acad. Sci., 85: 5166-5170.